Imaging probes for detecting apoptosis in vivo
Often, adverse effects of drug candidates are not discovered during preclinical testing. Various reasons may contribute to this, such as failing to detect subtle effects through classical histopathology techniques, to a failure in properly translating in vitro success to an in vivo setting.
See Below the Surface
Understand cellular process in the relevant biological environment. Imaging probes allow researchers to monitor disease progression and therapeutic efficacy over time in the same animal. Probes targeting enzyme activity, such as cathepsins and caspases also enable investigation of enzyme activity involved in disease pathologies in a variety of applications: animal imaging, microscopy and flow cytometry.